The protagonist of the game is a boy named Clayton, whose scientist father has developed a serum that can transform people into animals when it’s combined with clay. Suddenly, Jobo the witch doctor appears and demands the formula for the serum. The father refuses, to which Jobo replies by changing Clayton into a ball of clay and stealing away both his father and the serum.
Clayton vows to save his father in spite of his new form and embarks on a journey through his backyard, the Pacific, Japan, Africa, and finally outer space. The player uses samples of serum lying around in these levels to transform into one of five different animals (Muckster the Cat, Doh-Doh the Duck, Oozy the Mouse, Goopy the Guppy, and Globmeister the Gopher) to best fit with the environment and make it to the end of the level.
Special abilities that are in a clay ball transform Clayton into helpful animals as he races the clock to collect as much as possible and still makes it to the end, jumping over obstacles and attacking with the animal in use. Clayton must also be careful not to be hit while a blob or he’ll die.