The game includes various field conditions and audibles. The console versions use passwords for saves. It is played from above and behind the quarterback rather than from the side as most games of the time. As in the previous version, no actual NFL teams are included due to the lack of NFL or NFLPA licenses for authentic teams or player names.
In the 1990 Sega Genesis release, only a total of 16 teams are available. Each team was based unofficially on teams from the 1990 NFL season. The following generic teams are included, with colors based on the local NFL team: Buffalo, Miami, New England, Cincinnati, Houston, Pittsburgh, Denver, Kansas City, New York City (colors based on Giants), Philadelphia, Washington, Chicago, Minnesota, Atlanta, Los Angeles (colors based on Rams) and San Francisco. An All-Madden team is included as a bonus.
The SNES release features twenty-eight teams and the All-Madden team. Like in the Sega Genesis release, they are all generic, but each NFL city is represented and uses their respective colors (for instance, Cleveland’s team colors are orange and brown). New York and Los Angeles’ teams are again represented by the Giants’ and Rams’ colors, meaning each city is only represented once. To fill out the team roster, teams from “Oakland” and “New Jersey” were added, with the former wearing silver and black like the Raiders and the latter green and white like the Jets.